Is Psilocybin Legal in Colorado?

Key facts

• Federal law still lists psilocybin as a Schedule I controlled substance in every U.S. state.
• Colorado's page was last reviewed on 2026-05-15.
• Colorado has a state-level regulated framework; it is not the same thing as ordinary retail legalization.
• 1 city-level move are tracked on this page.
• This page is educational journalism, not legal advice.
• It does not provide sourcing, buying, or cultivation guidance.

Notable recent moves

Colorado voters approved Proposition 122, the Natural Medicine Health Act, in 2022.

Denver had already passed Initiative 301 in 2019, making adult psilocybin possession a low enforcement priority.

Colorado's framework is broader than Oregon's and includes state rulemaking around natural medicine businesses and facilitators.

Active bills

No active statewide psilocybin bill is tracked for this page as of last review.

Decriminalized cities

• Denver (2019)

Frequently asked questions

Is psilocybin legal in Colorado?

Colorado has a regulated state framework, but psilocybin is still federally Schedule I and is not simply legal for ordinary retail sale.

Can I be prosecuted for psilocybin possession in Colorado?

Possession can still create legal risk, especially outside a licensed or otherwise legally protected context. Ask a qualified Colorado attorney for advice on a real situation.

Does decriminalization in Denver make psilocybin legal statewide?

No. A city policy in Denver does not legalize psilocybin across Colorado and usually does not create a lawful sales system.

Is there legal psilocybin therapy in Colorado?

Colorado has a regulated service or natural medicine framework. Readers should use current agency rules to understand who can provide services and where.

Where should I check the latest Colorado rules?

Start with official state statutes, agency pages, and local government notices. This page is an educational snapshot reviewed on 2026-05-15.